While currently there is no cure for Celiac and strict adherence to a gluten-free diet is the only treatment, research on future treatment methods is being conducted by leading Celiac research centers and pharmaceutical companies around the globe. Perhaps one day there will be a pill available to take in addition to following a gluten-free diet (i.e. in the case of accidental gluten ingestion) or a vaccine (for prevention & treatment). Recent studies include: the therapeutic drugs AT-1001 Larazotide Acetate (Alba) and ALV-003 (Alvine). ImmusanT, a privately held biotechnology company located in Cambridge, MA, raised $20 million in financing to advance development of the immunotherapeutic Nexvax2 vaccine,which is currently the only “disease modifying” (would be able to consume gluten, without issue) treatment. Avaxia Biologics, out of Lexington, MA has received several grants to study a therapeutic treatment (AVX-470) as well. BioLineRx announced in September that pre-clinical results demonstrated safety of BL-7010, an oral therapeutic treatment. In Valencia, Spain clinical trials are being conducted on Biopolis’ Probiotic ES1. Studies involve several phases and can take many years to complete, but future treatment methods look promising. Research is also underway in Italy and the Netherlands using stem cell transplants which could one day restore gluten tolerance to celiacs.
The University of Chicago’s Celiac Research Center, among others, is at the forefront of research and education. Their annually published Research Summary Report outlines exciting discoveries which most certainly will have a great impact on the diagnosis and treatment of Celiac Disease. Open HERE to view a copy of their most current Year-End Research Report (Nov. 2014). “There is today strong evidence that a cure that would allow to freely eat gluten is possible. However, it is further down the road and may take 10-20 years to be available to patients with celiac disease” Dr. Dr. Bana Jabri, professor at University of Chicago and one of the world’s leading researchers of celiac disease (as noted in Media Planet article (6.2013).
For research being conducted at other notable US Celiac Research Centers please visit “Resources”, for a listing of nationwide centers to contact.
National Institutes of Health’s Clinical Trials.gov http://clinicaltrials.gov/search/term=(celiac+disease)+%5BCONDITION%5D
U.S. National Library of Medicine – National Institutes of Health’s PubMed.gov http://www.ncbi.nlm.nih.gov/pubmed?term=celiac
(Alvine’s ALV003 … enzymes to break down gluten) http://www.marketwatch.com/story/alvine-pharmaceuticals-alv003-receives-fast-track-designation-from-the-fda-for-the-potential-treatment-of-celiac-disease-2012-09-05
(Avaxia Biologics’ AVX-470) http://www.marketwatch.com/story/avaxia-biologics-awarded-15-million-phase-ii-sbir-grant-from-nih-to-develop-oral-antibody-therapeutic-for-inflammatory-bowel-disease-2012-03-19
(ImmusanT’s Nexvax2 vaccine … blocks immune response to gluten) (2/26/17) ImmusanT’s celiac disease immunotherapy passes first clinical test; past articles: http://www.immusant.com/wp-content/uploads/2011/06/ImmusanT-Series-B-Press-Release-FINAL-12.22.2014.pdf ; http://celiaccorner.com/celiac-gluten-free/vaccine-for-celiac-manufactured-and-tested-in-massachusetts/; http://www.pharmiweb.com/pressreleases/pressrel.asp?ROW_ID=104065#.VG58SvnF9-4 http://www.fiercebiotech.com/press-releases/immusant-raises-20-million-series-financing-advance-immunotherapeutic-and-d ; http://celiaccorner.com/celiac-gluten-free-blog/immusant-initiates-clinical-trials-of-nexvax2-first-ever-therapeutic-vaccine-for-celiacs/ ; http://www.marketwatch.com/story/immusant-names-ferdinand-e-massari-as-chief-medical-officer-2013-09-09
(BioLineRx’s BL-7010) (8/2014: http://www.businesswire.com/news/home/20140821005350/en/BioLineRx-Receives-Notice-Allowance-Patent-BL-7010-Covering#.U_dyFfldV-4 (7/2014: BioLineRx Announces Results from Phase 1/2 Study for Celiac Treatment ; (6/2014: http://www.marketwatch.com/story/biolinerx-receives-notice-of-allowance-for-us-patent-covering-novel-treatment-for-celiac-disease-2014-06-11 ; http://online.wsj.com/article/PR-CO-20130924-903110.html http://www.celiac.org/images/stories/PDF/bioline.pdf http://online.wsj.com/article/PR-CO-20130828-904762.html ; (3.10.14) http://www.marketwatch.com/story/biolinerx-completes-dose-escalation-stage-of-phase-12-study-for-novel-celiac-treatment-2014-03-10?reflink=MW_news_stmp
(Biopolis’ ES1, probiotic strain – Spain) http://ow.ly/fMM5m
(University of Washington’s KumaMax) (5/2015) http://www.komonews.com/news/health/UW-Researchers-developing-cure-for-celiac-disease-302653671.html?tab=video&c=y ; https://depts.washington.edu/uwc4c/news-events/uws-promising-therapeutic-for-celiac-disease-featured-in-chemical-and-engineering-news/
Miscellaneous articles relating to therapeutic treatments/research in the works (around the globe):
Common bacteria show promise for treating celiac disease (from 2016) — (posted 2.26.17) ScienceDaily
Promising Celiac Disease Therapies On the Horizon (3.9.15), uk.reuters.com
Though we try to keep up with the latest in future therapeutic treatments, certainly there are other studies being conducted worldwide which we have not included here.
You can help fund research by making a donation to a
Celiac Research Center! Another way in which to help further Celiac
research is by participating in a research study if you have Celiac, thus contributing to
advancements in treatment methods and ultimately helping
the entire Celiac community!
In addition to the request for participation for clinical trial noted above (Alba), check here for other requests to participate in a research study! http://celiaccorner.com/current-petitions-relating-to-food-allergens/
Visit “Celiac News and Articles” for informative medical and lifestyle articles.